What are the causes of hypogonadism

Hypogonadism - what is it actually?

As Hypogonadism becomes a Underactive gonads (= Gonads). The male gonads are the Testiclesthat of women are the Ovaries. In men, hypogonadism leads to a reduced testosterone level, which in some cases has considerable health consequences.

How does hypogonadism come about?

To understand how hypogonadism develops, we need to look at the process of testosterone production:

The Hypothalamus The hormone gonadoliberin (= GnHR: Gonadotropin-Releasing Hormone) is released in the diencephalon. Gonadoliberin stimulates the Pituitary gland (Pituitary gland) to release gonadotropins. This is a special group of hormones. These gonadotropins in turn stimulate testosterone production and release in the Testicles.

If this process is disturbed at one point, one speaks of Hypogonadism and a Testosterone deficiency arises.

What types of hypogonadism are there?

Primary hypogonadism:

Organ dysfunction of the gonads, i.e. the testicles or ovaries. This often leads to an excessive production of gonadotropins, so that one also speaks of hypergonadotropic hypogonadism (hyper = too much).

Secondary hypogonadism:

Disorder at the level of the pituitary gland in which the gonadotropins are formed. As a result, too few gonadotropins are released, which is called hypogonadotropic hypogonadism (hypo = too little).

Tertiary hypogonadism:

Disruption of the hypothalamus with reduced or absent release of gonadoliberin. This form is very rare.

What are the causes of the disease?

Depending on the form of hypogonadism, there are different causes:

Primary hypogonadism: disorder of the testicle

  • Congenital defect or chromosomal disorder
  • Damage from injury, inflammation, poison, medication, radiation, or surgery
  • tumor

Secondary hypogonadism: disorder of the pituitary gland

  • tumor
  • Damage from radiation, internal bleeding, or medication

Tertiary hypogonadism: disorder of the hypothalamus

  • tumor
  • infection
  • Damage from radiation or injury (e.g., traumatic brain injury)
  • Genetically conditioned

What are the consequences of hypogonadism?

The problem with hypogonadism is the resulting Testosterone deficiency. For one thing, such a deficiency affects that physical and mental well-being. Affected people lose muscle mass and get more belly fat in return. You are tired, listless, and have erectile dysfunction. Depression and hot flashes can also occur. On the other hand, a deficiency can Seriously affect your health. Testosterone deficiency favors diseases such as:

  • Muscle and bone loss (osteoporosis)
  • Erectile dysfunction and impotence
  • Type 2 diabetes
  • Cardiovascular diseases, such as heart attacks and strokes
  • Anemia
  • Metabolic syndrome: obesity, high blood pressure, increased cholesterol and blood sugar levels